Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models
We explored whether the combination of lurbinectedin (PM01183) with the antimetabolite gemcitabine could result in a synergistic antitumor effect in pancreatic ductal adenocarcinoma (PDA) mouse models. We also studied the contribution of lurbinectedin to this synergism. This drug presents a dual pha...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2016-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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