Administration of chloroquine or hydroxychloroquine through feeding tubes: new challenges in times of coronavirus pandemic

The use of chloroquine and hydroxychloroquine as off-label treatments for covid-19 disease is a resort for critical care patients under enteral nutrition (EN). However, the use of solid pharmaceutical forms of these drugs through feeding tubes can pose a challenge to the health care team. Therefore,...

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Main Authors: Mariana Martins Gonzaga do Nascimento (Author), Sandra Regina Santos (Author), Cristiane de Paula Rezende (Author), Raquel Linhares Bello de Araújo (Author)
Format: Book
Published: São Paulo State University (UNESP), 2020-04-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Mariana Martins Gonzaga do Nascimento  |e author 
700 1 0 |a Sandra Regina Santos  |e author 
700 1 0 |a Cristiane de Paula Rezende  |e author 
700 1 0 |a Raquel Linhares Bello de Araújo  |e author 
245 0 0 |a Administration of chloroquine or hydroxychloroquine through feeding tubes: new challenges in times of coronavirus pandemic 
260 |b São Paulo State University (UNESP),   |c 2020-04-01T00:00:00Z. 
500 |a 1808-4532 
500 |a 2179-443X 
520 |a The use of chloroquine and hydroxychloroquine as off-label treatments for covid-19 disease is a resort for critical care patients under enteral nutrition (EN). However, the use of solid pharmaceutical forms of these drugs through feeding tubes can pose a challenge to the health care team. Therefore, we performed a review of literature regarding administration of chloroquine and hydroxychloroquine through feeding tubes. For this end, a search was performed on PubMed and Lilacs database using key-words and free terms referring to drug administration via feeding tubes, and, specifically chloroquine and hydroxychloroquine. Also, a search on Micromedex® database and on the Handbook of Drug Administration via Enteral Feeding Tubes were performed. A total of 1.784 articles were retrieved. However, 4 articles fitted in the inclusion criteria. Two articles exploring the administration of chloroquine via feeding tubes on children with malaria found no difference on clinical results or tolerability when comparing it with oral or intramuscular administration. Other article showed full dispersion of hydroxychloroquine on water after crushing with mortar and pestle. A review found no information regarding the administration of hydroxychloroquine via postpyloric feeding tubes. No information was found on Micromedex® or the consulted Handbook; however, they pointed out the interaction between chloroquine and multivalent ions if coadministered. 
546 |a EN 
690 |a enteral nutrition 
690 |a chloroquine 
690 |a hydroxychloroquine 
690 |a Pharmaceutical industry 
690 |a HD9665-9675 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Revista de Ciências Farmacêuticas Básica e Aplicada, Vol 40, Pp 1-3 (2020) 
787 0 |n http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/640 
787 0 |n https://doaj.org/toc/1808-4532 
787 0 |n https://doaj.org/toc/2179-443X 
856 4 1 |u https://doaj.org/article/e06b0b9e08c04402a6b46c157b711ec6  |z Connect to this object online.