Mechanism and Improved Dissolution of Glycyrrhetinic Acid Solid Dispersion by Alkalizers

• Main Authors: Luning Dong (Author), Yaping Mai (Author), Qiang Liu (Author), Wannian Zhang (Author), Jianhong Yang (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2020-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The purpose of this study was to increase the dissolution of glycyrrhetinic acid (GA) by preparing ternary solid dispersion (TSD) systems containing alkalizers, and to explore the modulating mechanism of alkalizers in solid dispersion systems. GA TSDs were prepared by hot melt extrusion (HME) with K...