Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women
Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel-Palade bodies, which can affect activity of ADAMTS-13 metalloproteinase (a disintegrin and metallo...
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2023-03-01T00:00:00Z.
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001 | doaj_e10a9c7e62b1488ebe6bf8e9e9fe78d1 | ||
042 | |a dc | ||
100 | 1 | 0 | |a N. R. Gashimova |e author |
700 | 1 | 0 | |a K. N. Grigoreva |e author |
700 | 1 | 0 | |a V. O. Bitsadze |e author |
700 | 1 | 0 | |a L. L. Pankratyeva |e author |
700 | 1 | 0 | |a J. Kh. Khizroeva |e author |
700 | 1 | 0 | |a M. V. Tretyakova |e author |
700 | 1 | 0 | |a Ya. M. Shammut |e author |
700 | 1 | 0 | |a E. Iu. Iupatov |e author |
700 | 1 | 0 | |a V. I. Tsibizova |e author |
700 | 1 | 0 | |a J.-K. Gris |e author |
700 | 1 | 0 | |a D. V. Blinov |e author |
700 | 1 | 0 | |a A. D. Makatsariya |e author |
245 | 0 | 0 | |a Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women |
260 | |b IRBIS LLC, |c 2023-03-01T00:00:00Z. | ||
500 | |a 2313-7347 | ||
500 | |a 2500-3194 | ||
500 | |a 10.17749/2313-7347/ob.gyn.rep.2023.386 | ||
520 | |a Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel-Palade bodies, which can affect activity of ADAMTS-13 metalloproteinase (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) and the ADAMTS-13/vWF axis previously shown by us to be altered in non-pregnant women with severe COVID-19. Aim: to study a clinical role of hemostasis activation particularly ADAMTS-13/vWF axis in pregnant women after COVID-19. Materials and Methods. A prospective case-control study was conducted with pregnant women (n = 135) divided into 3 groups: group 1 included 45 women with prior COVID-19 during pregnancy, group 2 - 45 women in the acute phase of the infection during pregnancy, group 3 - 45 healthy pregnant women. The level of vWF and ADAMTS-13 was assessed in all patients. Results. The concentration of vWF antigen (vWF:Ag) in the acute period of the disease in pregnant women with COVID-19 was significantly higher compared to the control group (p < 0.001). ADAMTS-13 level in pregnant women after COVID-19 did not differ from that of in control group, while vWF level was significantly higher in 66.7 % (30/45). The ADAMTS-13/vWF ratio was increased and significantly differed both in pregnant patients during the acute period of the disease (p < 0.001) and pregnant women after infection (p = 0.0002) compared with the control group. Conclusion. Our results show that endotheliopathy was prominently manifested in pregnant women with COVID-19 and persisted for several months after disease. The ADAMTS-13/vWF ratio determines the pathway functioning, the risk of microcirculation disorders and clinical complications. | ||
546 | |a RU | ||
690 | |a pregnancy | ||
690 | |a covid-19 | ||
690 | |a adamts-13 | ||
690 | |a von willebrand factor | ||
690 | |a vwf | ||
690 | |a Gynecology and obstetrics | ||
690 | |a RG1-991 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Акушерство, гинекология и репродукция, Vol 17, Iss 1, Pp 8-17 (2023) | |
787 | 0 | |n https://www.gynecology.su/jour/article/view/1560 | |
787 | 0 | |n https://doaj.org/toc/2313-7347 | |
787 | 0 | |n https://doaj.org/toc/2500-3194 | |
856 | 4 | 1 | |u https://doaj.org/article/e10a9c7e62b1488ebe6bf8e9e9fe78d1 |z Connect to this object online. |