Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger - Lessons From Knockout Mice
We used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mouse hearts after ischemia/reperfusion and th...
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| Main Authors: | , |
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| Format: | Book |
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Elsevier,
2004-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | We used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mouse hearts after ischemia/reperfusion and the infracted size was significantly smaller in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury, and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury. Keywords:: Na+/Ca2+ exchanger (NCX), knockout mouse, heart, ischemia/reperfusion injury |
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| Item Description: | 1347-8613 10.1254/jphs.fmj04002x5 |