Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis

• Asıl Yazarlar: Marwa E. Abdelaziz (Yazar), Mostafa M. M. El-Miligy (Yazar), Salwa M. Fahmy (Yazar), Marwa M. Abu-Serie (Yazar), Aly A. Hazzaa (Yazar), Mona A. Mahran (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

AbstractNew aromatic O-alkyl pyridine derivatives were designed and synthesised as Proviral Integration Moloney (PIM)-1 kinase inhibitors. 4c and 4f showed potent in vitro anticancer activity against NFS-60, HepG-2, PC-3, and Caco-2 cell lines and low toxicity against normal human lung fibroblast Wi...