Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

• Main Authors: Jeanluc Bertrand (Author), Hana Dostálová (Author), Vladimír Kryštof (Author), Radek Jorda (Author), Thalía Delgado (Author), Alejandro Castro-Alvarez (Author), Jaime Mella (Author), David Cabezas (Author), Mario Faúndez (Author), Christian Espinosa-Bustos (Author), Cristian O. Salas (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and FLT3-ITD as part of our program to develop 2,6,9-trisubstituted purine derivatives as inhibitors of oncogenic kinases. The design was inspired by the chemical structures of well-known kinase inhibitors and our previou...