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Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF

On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10...

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Bibliographic Details
Main Authors: T. A. Antipova (Author), I. O. Logvinov (Author), S. V. Nikolaev (Author), S. V. Kruglov (Author), A. V. Tarasiuk (Author), P. I. Antipov (Author), T. A. Gudasheva (Author), S. B. Seredenin (Author)
Format: Book
Published: LLC "Publisher OKI", 2016-03-01T00:00:00Z.
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Summary:On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10-6M)) evoke activation of two main signal cascades - PI3/Akt and MAP/Erk, while mimetic the 4th loop of NGF (GK-2 (10-8M)) only one - a PI3/Akt-way.
Item Description:2587-7836
2686-8830

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