Cover Image

Brain-Targeted Intranasal Delivery of Zotepine Microemulsion: Pharmacokinetics and Pharmacodynamics

The purpose of our study was to improve the solubility, bioavailability, and efficacy of zotepine (ZTP) by brain-targeted intranasal delivery of microemulsion (ME) and its physicochemical properties, the pharmacokinetic and pharmacodynamic parameters were evaluated. The optimized ME formulations con...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sravanthi Reddy Pailla (Author), Sunitha Sampathi (Author), Vijayabhaskarreddy Junnuthula (Author), Sravya Maddukuri (Author), Sujatha Dodoala (Author), Sathish Dyawanapelly (Author)
Format:	Book
Published:	MDPI AG, 2022-04-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Therapeutic Potential of Naringenin Nanosuspension: In Vitro and In Vivo Anti-Osteoporotic Studies
by: Sonia Gera, et al.
Published: (2022)

Development of Biocompatible Ciprofloxacin-Gold Nanoparticle Coated Sutures for Surgical Site Infections
by: Sunitha Sampathi, et al.
Published: (2022)

Pharmacokinetics and Anti-Diabetic Studies of Gliclazide Nanosuspension
by: Sunitha Sampathi, et al.
Published: (2022)

Polymeric Micelles for Breast Cancer Therapy: Recent Updates, Clinical Translation and Regulatory Considerations
by: Vijayabhaskarreddy Junnuthula, et al.
Published: (2022)

Fast-Fed Variability: Insights into Drug Delivery, Molecular Manifestations, and Regulatory Aspects
by: Nagarjun Rangaraj, et al.
Published: (2022)

Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery
by: Thi-, et al.
Published: (2022)

Comparative evaluation of intranasally delivered quetiapine loaded mucoadhesive microemulsion and polymeric nanoparticles for brain targeting: pharmacokinetic and gamma scintigraphy studies
by: Brijesh Shah, et al.
Published: (2021)

Zotepine loaded lipid nanoparticles for oral delivery: development, characterization, and in vivo pharmacokinetic studies
by: B. Nagaraj, et al.
Published: (2020)

Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route
by: Rudree Pathak, et al.
Published: (2014)

Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route
by: Surjyanarayan Mandal, et al.
Published: (2015)

Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting
by: Sara Meirinho, et al.
Published: (2023)

Repurposing ibuprofen-loaded microemulsion for the management of Alzheimer's disease: evidence of potential intranasal brain targeting
by: Ming Ming Wen, et al.
Published: (2021)

Development And Evaluation Of Peppermint Oil Containing Microemulsions For Intranasal Delivery
by: Darshana S Jain, et al.
Published: (2011)

Formulation and kinetic modeling of curcumin loaded intranasal mucoadhesive microemulsion
by: B Mikesh Patel, et al.
Published: (2012)

Selective separation, detection of zotepine and mass spectral characterization of degradants by LCâMS/MS/QTOF
by: M.V.N. Kumar Talluri, et al.
Published: (2014)

Review on the Scale-Up Methods for the Preparation of Solid Lipid Nanoparticles
by: Sakshi V. Khairnar, et al.
Published: (2022)

Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution
by: Yunliang Guo, et al.
Published: (2019)

Comparative pharmacodynamics of intranasal and enteral administration of captopril for uncomplicated hypertensive crises
by: I. L. Kechyn, et al.
Published: (2021)

Pharmacokinetics of intranasal amiloride in healthy volunteers
by: Venkata K. Yellepeddi, et al.
Published: (2023)

Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics
by: Fatouh AM, et al.
Published: (2017)

Microemulsion-Based Media in Nose-to-Brain Drug Delivery
by: Anna Froelich, et al.
Published: (2021)

Pharmacokinetics of Intranasally Administered Dexmedetomidine in Chinese Children
by: Cheng-Yu Wang, et al.
Published: (2019)

Intranasal Delivery of a Silymarin Loaded Microemulsion for the Effective Treatment of Parkinson's Disease in Rats: Formulation, Optimization, Characterization, and In Vivo Evaluation
by: Mohd Imran, et al.
Published: (2023)

Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration
by: Dongmei Meng, et al.
Published: (2014)

The Pharmacokinetics and Pharmacodynamics of Iron Preparations
by: Susanna Burckhardt, et al.
Published: (2011)

Isavuconazole Pharmacokinetics and Pharmacodynamics in Children
by: Hirsh Elhence, et al.
Published: (2022)

Neurodevelopmental Toxic Effects of Food Additives Used in Energy Drinks on Developing Rats
by: Revathi Boyina, et al.
Published: (2021)

Intranasal delivery of paeoniflorin nanocrystals for brain targeting
by: Chaoyin Wu, et al.
Published: (2020)

Intranasal epinephrine in dogs: Pharmacokinetic and heart rate effects
by: Kenneth L. Dretchen, et al.
Published: (2020)

Surface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo pharmacokinetic assessment
by: Hibah M. Aldawsari, et al.
Published: (2022)

Docosahexaenoic acid-mediated, targeted and sustained brain delivery of curcumin microemulsion
by: Rajshree L. Shinde, et al.
Published: (2017)

The influence of telmisartan on metformin pharmacokinetics and pharmacodynamics
by: Jiagen Wen, et al.
Published: (2019)

Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib
by: Koen G. A. M. Hussaarts, et al.
Published: (2020)

Insights into the Pharmacogenetics of Tacrolimus Pharmacokinetics and Pharmacodynamics
by: Mercè Brunet, et al.
Published: (2022)

The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
by: Andrzej Czyrski, et al.
Published: (2021)

The Blood-Brain Barrier and Pharmacokinetic/Pharmacodynamic Optimization of Antibiotics for the Treatment of Central Nervous System Infections in Adults
by: Nicholas Haddad, et al.
Published: (2022)

Intranasal nanocrystals of tadalafil: in vitro characterisation and in vivo pharmacokinetic study
by: Ruba S. Darweesh, et al.
Published: (2024)

Evaluation of pharmacokinetics of warfarin from validated pharmacokinetic-pharmacodynamic model
by: Kannan Sridharan, et al.
Published: (2021)

An icaritin-loaded microemulsion based on coix oil for improved pharmacokinetics and enhanced antitumor efficacy
by: Huating Zeng, et al.
Published: (2022)

Microemulsion a Chemical Nanoreactor
Published: (2019)