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Assessment of the Drug Interaction Potential of Unconjugated and GalNAc3-Conjugated 2'-MOE-ASOs

Antisense oligonucleotides are metabolized by nucleases and drug interactions with small drug molecules at either the cytochrome P450 (CYP) enzyme or transporter levels have not been observed to date. Herein, a comprehensive in vitro assessment of the drug-drug interaction (DDI) potential was carrie...

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Main Authors: Colby S. Shemesh (Author), Rosie Z. Yu (Author), Mark S. Warren (Author), Michael Liu (Author), Mirza Jahic (Author), Brandon Nichols (Author), Noah Post (Author), Song Lin (Author), Daniel A. Norris (Author), Eunju Hurh (Author), Jane Huang (Author), Tanya Watanabe (Author), Scott P. Henry (Author), Yanfeng Wang (Author)
Format: Book
Published: Elsevier, 2017-12-01T00:00:00Z.
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