The Utilisation Of Thermal Methods For The Screening Of Three Component Co-amorphous Systems
Indomethacin and piroxicam are known to become amorphous upon rapid cooling after melting. Multiple three-component co-amorphous mixtures have been produced via a melt quench method to evaluate the influence of the third component on stability and physical properties on the co-amorphous mixture of p...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
University of Huddersfield Press,
2018-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Indomethacin and piroxicam are known to become amorphous upon rapid cooling after melting. Multiple three-component co-amorphous mixtures have been produced via a melt quench method to evaluate the influence of the third component on stability and physical properties on the co-amorphous mixture of piroxicam and indomethacin. These have then been tested using thermal gravimetric analysis, differential scan calorimetry and hot stage microscopy. Results have confirmed the creation of a three-component co-amorphous system. |
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| Item Description: | 10.5920/bjpharm.2017.21 2058-8356 |