Levels of Plasma Coenzyme Q₁₀ Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly

• Main Authors: Rocío de la Bella-Garzón (Author), Cristina Fernández-Portero (Author), David Alarcón (Author), Josué G. Amián (Author), Guillermo López-Lluch (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Coenzyme Q₁₀ (CoQ₁₀) is an essential factor for mitochondrial activity and antioxidant protection of cells, tissues and plasma lipoproteins. Its deficiency has been associated with aging progression in animals and humans. To determine if CoQ₁₀ levels in plasma can be associated with frailty in elderly people (aged > 65), we studied the relationship of CoQ₁₀ levels in blood with other parameters in plasma and with the physical activity and capacity in aged people. Our results indicate that high CoQ₁₀ levels are directly associated with lower cardiovascular risk measured by the quotient total cholesterol/HDL cholesterol. Furthermore, high CoQ₁₀ levels were found in people showing higher physical activity, stronger muscle capacity. CoQ₁₀ also showed a strong inverse relationship with sedentarism and the up and go test, which is considered to be a frailty index. Interestingly, we found gender differences, indicating stronger correlations in women than in men. The importance of the maintenance of CoQ₁₀ levels in elderly people to avoid sarcopenia and frailty in elderly people is discussed.

Item Description

10.3390/antiox11020279
2076-3921