The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review

Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muric...

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Main Authors: David Andi Wijaya (Author), Melva Louisa (Author), Heri Wibowo (Author), Aslim Taslim (Author), Tiara Bunga Mayang Permata (Author), Handoko Handoko (Author), Endang Nuryadi (Author), Henry Kodrat (Author), Soehartati Argadikoesoema Gondhowiardjo (Author)
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Published: Shahrekord University of Medical Sciences, 2021-04-01T00:00:00Z.
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MARC

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042 |a dc 
100 1 0 |a David Andi Wijaya  |e author 
700 1 0 |a Melva Louisa  |e author 
700 1 0 |a Heri Wibowo  |e author 
700 1 0 |a Aslim Taslim  |e author 
700 1 0 |a Tiara Bunga Mayang Permata  |e author 
700 1 0 |a Handoko Handoko  |e author 
700 1 0 |a Endang Nuryadi  |e author 
700 1 0 |a Henry Kodrat  |e author 
700 1 0 |a Soehartati Argadikoesoema Gondhowiardjo  |e author 
245 0 0 |a The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review 
260 |b Shahrekord University of Medical Sciences,   |c 2021-04-01T00:00:00Z. 
500 |a 2345-5004 
500 |a 10.34172/jhp.2021.18 
520 |a Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent. 
546 |a EN 
690 |a annona muricata 
690 |a radiotherapy 
690 |a radio-sensitivity 
690 |a plant extract 
690 |a bioactive compounds 
690 |a Medicine (General) 
690 |a R5-920 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Journal of HerbMed Pharmacology, Vol 10, Iss 2, Pp 166-178 (2021) 
787 0 |n http://herbmedpharmacol.com/PDF/jhp-10-166.pdf 
787 0 |n https://doaj.org/toc/2345-5004 
856 4 1 |u https://doaj.org/article/e26e292dc78f4be7b5ea47d55a99a026  |z Connect to this object online.