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Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents

7-Ethyl-10-hydroxycamptothecin (SN38), a highly potent metabolite of irinotecan, has an anticancer efficacy 100-1000 folds more than irinotecan in vitro. However, the clinical application of SN38 has been limited due to the very narrow therapeutic window and poor water solubility. Herein, we report...

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Bibliographic Details
Main Authors:	Chao Yang (Author), An-Jie Xia (Author), Cheng-Hao Du (Author), Ming-Xing Hu (Author), You-Ling Gong (Author), Rong Tian (Author), Xin Jiang (Author), Yong-Mei Xie (Author)
Format:	Book
Published:	Frontiers Media S.A., 2022-11-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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