Emergence of multidrug-resistant Providencia rettgeri isolates co-producing NDM-1 carbapenemase and PER-1 extended-spectrum β-lactamase causing a first outbreak in Korea
Abstract Background Nosocomial outbreak due to carbapenem-resistant Enterobacteriaceae has become serious challenge to patient treatment and infection control. We describe an outbreak due to a multidrug-resistant Providencia rettgeri from January 2016 to January 2017 at a University Hospital in Seou...
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2018-05-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_e2981bfdd1af4ea2a8a2961cdb0c5f21 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Saeam Shin |e author |
| 700 | 1 | 0 | |a Seok Hoon Jeong |e author |
| 700 | 1 | 0 | |a Hyukmin Lee |e author |
| 700 | 1 | 0 | |a Jun Sung Hong |e author |
| 700 | 1 | 0 | |a Min-Jeong Park |e author |
| 700 | 1 | 0 | |a Wonkeun Song |e author |
| 245 | 0 | 0 | |a Emergence of multidrug-resistant Providencia rettgeri isolates co-producing NDM-1 carbapenemase and PER-1 extended-spectrum β-lactamase causing a first outbreak in Korea |
| 260 | |b BMC, |c 2018-05-01T00:00:00Z. | ||
| 500 | |a 10.1186/s12941-018-0272-y | ||
| 500 | |a 1476-0711 | ||
| 520 | |a Abstract Background Nosocomial outbreak due to carbapenem-resistant Enterobacteriaceae has become serious challenge to patient treatment and infection control. We describe an outbreak due to a multidrug-resistant Providencia rettgeri from January 2016 to January 2017 at a University Hospital in Seoul, Korea. Methods A total of eight non-duplicate P. rettgeri isolates were discovered from urine samples from eight patients having a urinary catheter and admitted in a surgical intensive care unit. The β-lactamase genes were identified using polymerase chain reaction and direct sequencing, and strain typing was done with pulsed-field gel electrophoresis (PFGE). Results All isolates showed high-level resistance to extended-spectrum cephalosporins, aztreonam, meropenem, ertapenem, ciprofloxacin, and amikacin. They harbored the bla NDM-1 carbapenemase and the bla PER-1 type extended-spectrum β-lactamases genes. PFGE revealed that all isolates from eight patients were closely related strains. Conclusions The 13-month outbreak ended following reinforcement of infection control measures, including contact isolation precautions and environmental disinfection. This is the first report of an outbreak of a P. rettgeri clinical isolates co-producing NDM-1 and PER-1 β-lactamase. | ||
| 546 | |a EN | ||
| 690 | |a Providencia rettgeri | ||
| 690 | |a Outbreak | ||
| 690 | |a Urinary tract infection | ||
| 690 | |a NDM-1 | ||
| 690 | |a PER-1 | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Infectious and parasitic diseases | ||
| 690 | |a RC109-216 | ||
| 690 | |a Microbiology | ||
| 690 | |a QR1-502 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Annals of Clinical Microbiology and Antimicrobials, Vol 17, Iss 1, Pp 1-6 (2018) | |
| 787 | 0 | |n http://link.springer.com/article/10.1186/s12941-018-0272-y | |
| 787 | 0 | |n https://doaj.org/toc/1476-0711 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e2981bfdd1af4ea2a8a2961cdb0c5f21 |z Connect to this object online. |