Emergence of multidrug-resistant Providencia rettgeri isolates co-producing NDM-1 carbapenemase and PER-1 extended-spectrum β-lactamase causing a first outbreak in Korea

Abstract Background Nosocomial outbreak due to carbapenem-resistant Enterobacteriaceae has become serious challenge to patient treatment and infection control. We describe an outbreak due to a multidrug-resistant Providencia rettgeri from January 2016 to January 2017 at a University Hospital in Seou...

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Main Authors: Saeam Shin (Author), Seok Hoon Jeong (Author), Hyukmin Lee (Author), Jun Sung Hong (Author), Min-Jeong Park (Author), Wonkeun Song (Author)
Format: Book
Published: BMC, 2018-05-01T00:00:00Z.
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001 doaj_e2981bfdd1af4ea2a8a2961cdb0c5f21
042 |a dc 
100 1 0 |a Saeam Shin  |e author 
700 1 0 |a Seok Hoon Jeong  |e author 
700 1 0 |a Hyukmin Lee  |e author 
700 1 0 |a Jun Sung Hong  |e author 
700 1 0 |a Min-Jeong Park  |e author 
700 1 0 |a Wonkeun Song  |e author 
245 0 0 |a Emergence of multidrug-resistant Providencia rettgeri isolates co-producing NDM-1 carbapenemase and PER-1 extended-spectrum β-lactamase causing a first outbreak in Korea 
260 |b BMC,   |c 2018-05-01T00:00:00Z. 
500 |a 10.1186/s12941-018-0272-y 
500 |a 1476-0711 
520 |a Abstract Background Nosocomial outbreak due to carbapenem-resistant Enterobacteriaceae has become serious challenge to patient treatment and infection control. We describe an outbreak due to a multidrug-resistant Providencia rettgeri from January 2016 to January 2017 at a University Hospital in Seoul, Korea. Methods A total of eight non-duplicate P. rettgeri isolates were discovered from urine samples from eight patients having a urinary catheter and admitted in a surgical intensive care unit. The β-lactamase genes were identified using polymerase chain reaction and direct sequencing, and strain typing was done with pulsed-field gel electrophoresis (PFGE). Results All isolates showed high-level resistance to extended-spectrum cephalosporins, aztreonam, meropenem, ertapenem, ciprofloxacin, and amikacin. They harbored the bla NDM-1 carbapenemase and the bla PER-1 type extended-spectrum β-lactamases genes. PFGE revealed that all isolates from eight patients were closely related strains. Conclusions The 13-month outbreak ended following reinforcement of infection control measures, including contact isolation precautions and environmental disinfection. This is the first report of an outbreak of a P. rettgeri clinical isolates co-producing NDM-1 and PER-1 β-lactamase. 
546 |a EN 
690 |a Providencia rettgeri 
690 |a Outbreak 
690 |a Urinary tract infection 
690 |a NDM-1 
690 |a PER-1 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
690 |a Infectious and parasitic diseases 
690 |a RC109-216 
690 |a Microbiology 
690 |a QR1-502 
655 7 |a article  |2 local 
786 0 |n Annals of Clinical Microbiology and Antimicrobials, Vol 17, Iss 1, Pp 1-6 (2018) 
787 0 |n http://link.springer.com/article/10.1186/s12941-018-0272-y 
787 0 |n https://doaj.org/toc/1476-0711 
856 4 1 |u https://doaj.org/article/e2981bfdd1af4ea2a8a2961cdb0c5f21  |z Connect to this object online.