Assessment of Salivary Interleukin-1β Levels in Patients with Gingivitis and Periodontitis: An Analytical Cross-Sectional Study

• Main Authors: Muntadhr A Al-Musawi (Author), Omar H. Ali (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2155-8213; 10.4103/denthyp.denthyp_148_22
• Keywords: elisa assay; interleukin-1 beta; gingivitis; periodontal disease; periodontitis; salivary biomarkers; Dentistry; RK1-715
• Source: Dental Hypotheses, Vol 14, Iss 1, Pp 3-6 (2023)

Introduction: The study aimed to analyze the level of salivary Interleukin-1 beta (IL-1β) in subjects with healthy periodontium and patients with gingivitis and periodontitis stage I-III. Methods: A total of 90 individuals participated in the research, separated into five groups, clinically healthy (n = 10), gingivitis (n = 20), stage I periodintitis (n = 20), stage II periodontitis (n = 20), and stage III periodontitis (n = 20). Level of salivary IL-1β was assessed using the enzyme-linked immunosorbent assay. Result: A statically significant difference (P < 0.001) found amongst study groups, further multiple group comparison revealed a statistically significant difference (P < 0.05) when comparing the experimental groups with control and when comparing gingivitis with stage II and III groups. Conclusion: Within the limitations of this cross-sectional study, IL-1β can be considered as a potential salivary biomarkers to differentiate between healthy and unhealthy periodontium.