Intraocular administration of tetramethylpyrazine hydrochloride to rats: a direct delivery pathway for brain targeting?

• Main Authors: Dan Mao (Author), Fang Li (Author), Qun Ma (Author), Manman Dai (Author), Huimin Zhang (Author), Luyu Bai (Author), Ning He (Author)
• Format: Bog
• Udgivet: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Fag: article
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The purpose of this study was to compare the pharmacokinetic profile of tetramethylpyrazine hydrochloride (TMPH) in rat plasma and tissues following intravenous (iv), intragastric (ig) and intraocular (io) administration. After io, ig and iv administration of a single dose at 10 mg/kg, tissue and pl...