The Effects of Vitamin D Supplementation on Anthropometric and Biochemical Indices in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

• Main Authors: Shahla Rezaei (Author), Reza Tabrizi (Author), Peyman Nowrouzi-Sohrabi (Author), Mohammad Jalali (Author), Mojtaba Shabani-Borujeni (Author), Shayan Modaresi (Author), Maryam Gholamalizadeh (Author), Saeid Doaei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background: Vitamin D was reported to be associated with non−alcoholic fatty liver disease (NAFLD). This systematic review and meta−analysis aimed to investigate the effects of the vitamin D supplementation on anthropometric and biochemical indices in patient with NAFLD.Methods: PubMed, Web of science, Scopus, and Embase databases were explored to identify all randomized controlled trial (RCT) investigating the effects of vitamin D supplementation on anthropometric and biochemical indices in patients with NAFLD. A random−effects model was used to pool weighted mean difference (WMD) and corresponding 95% confidence intervals (CIs). The statistical heterogeneity among the studies was assessed using I2 statistic (high ≥ 50%, low < 50%) and Cochran's Q−test.Results: Sixteen RCTs were included in this meta−analysis. The results identified that high−density lipoprotein−cholesterol (HDL−C) level significantly increased following vitamin D supplementation (P = 0.008). Vitamin D reduced body weight (P = 0.007), body mass index (P = 0.002), waist circumstance (WC) (P = 0.02), serum alanine transaminase (ALT) (P = 0.01), fasting blood sugar (FBS) (P = 0.01), homeostatic model assessment for insulin resistance (HOMA−IR) (P = 0.004), and calcium (P = 0.01). No significant changes were found on body fat, triglyceride (TG), total cholesterol, low−density lipoprotein−cholesterol (LDL−C), aspartate transaminase, alkaline phosphatase, gamma−glutamyl transferase, and adiponectin following vitamin D supplementation.Conclusion: Vitamin D had significant effects on anthropometric and biochemical indices including HDL−C, body weight, BMI, WC, serum ALT, serum FBS, HOMA−IR, and calcium. Vitamin D supplementation can be considered as an effective strategy in management of patients with NAFLD.Systematic Review Registration: [website], identifier [registration number]

Item Description

1663-9812
10.3389/fphar.2021.732496