Aerobic exercise training induces superior cardioprotection following myocardial ischemia reperfusion injury than a single aerobic exercise session in rats

• Main Authors: Juliana Pereira Borges (Author), Guilherme de Oliveira França (Author), Mariana Delgado Cruz (Author), Rômulo Lanza (Author), Alessandro Rodrigues do Nascimento (Author), Marcos Adriano Lessa (Author)
• Format: Book
• Published: Universidade Estadual Paulista (UNESP), 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1980-6574; 10.1590/s1980-6574201700si0011
• Keywords: ischemia and reperfusion; aerobic exercise training; Langendorff; Sports; GV557-1198.995; Sports medicine; RC1200-1245
• Source: Motriz: Revista de Educacao Fisica, Vol 23, Iss spe (2017)

Abstract AIM To compare the amount of cardioprotection induced by a single exercise session with those achieved after an 8-week aerobic exercise training following ischemia reperfusion injury in rats. METHODS Twenty-five male Wistar rats (250-300g) were assigned into a group submitted to physical training (TR; n=12) or a single maximal exercise session (EXE; n=13). Following sedentarism or physical training (8 weeks, 5 sessions/wk, 1h/session at 70% of maximal speed) both groups performed a maximal exercise test. Then, groups were submitted to ischemia reperfusion injury (30 min/1h) through an isolated heart protocol, in which left ventricle developed pressure was measured. RESULTS The TR group presented greater maximal oxygen consumption compared to the EXE group (77.25±20.41 vs 41.32±25.86 ml/Kg/min; P=0.003). Regarding left ventricle developed pressure, no differences were detected between groups at baseline (TR: 89.78±24.40 vs EXE: 81.37±31.84 mmHg; P=0.48). However, after reperfusion, the TR group presented superior intraventricular pressure than EXE group (37.94±18.34 vs 21.59±13.67 mmHg; P=0.03). CONCLUSION Eight-week aerobic training induced greater cardioprotection against ischemia reperfusion injury in rats compared to a single exercise session, due to an increased cardiac function. This suggests that exercise-induced cardioprotection is a multifactorial process that may involve different mediators according to the exercise duration.