Risk factors for patent ductus arteriosus in preterm neonates

• Main Authors: Novia Bernati (Author), Ria Nova (Author), Julniar M. Tasli (Author), Theodorus Theodorus (Author)
• Format: Book
• Published: Indonesian Pediatric Society Publishing House, 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Background The reported prevalences of patent ductus arteriosus (PDA) in preterm neonates vaty, and are currently unknown in Palembang. Birth weight, ges tational age, asphyxia, histoty of antenatal steroid use, hyaline membrane disease (HMD), race and ethnicity, are potential risk factors for PDA. Objective To determine the prevalence of PDA and its risk factors in preterm neonates at Mohammad Hoesin Hospital, Palembang. Methods This cross-sectional study was conducted from October 2011 to April 2012. Echocardiographic examinations were performed on 242 preterm neonates aged 15 hours to 7 days. Data was taken from medical records and interviews, and analyzed by Chi square and logistic regression analyses. Results Patent ductus arteriosus was found in 142 (58.7%) preterm neonates with a prevalence ratio of 1.43. Neonates with birthweight ::;;2,000 grams tended to have 1.9 (95% CI 1.17 to 3.32) rimes higher risk for PDA (P=0.01). Neonates ::;;JO weeks gestation were also at 1.9 rimes higher risk for PDA (P=0.16). Probabilities for PDA occurrence in neonates with asphyxia, without antenatal corticosteroids and HMD were 1.6 (95% CI 1.13 to 3.36) rimes, 1.3 (95%CI 0.73 to 2.50) times and 2.2 (95%CI 1.29 to 3.72) rimes higher risk for PDA, respectively (P=0.22, 0.41, and 0.005, respectively). Conclusion Birth weight and HMD are statistically significant risk factors of PDA, but the more significant one is HMD.

Item Description

0030-9311
2338-476X
10.14238/pi54.3.2014.132-6