Linggui Zhugan Decoction activates the SIRT1-AMPK-PGC1α signaling pathway to improve mitochondrial and oxidative damage in rats with chronic heart failure caused by myocardial infarction

• Main Authors: Siyi Yu (Author), Hang Qian (Author), Dawei Tian (Author), Mingming Yang (Author), Dongfeng Li (Author), Hao Xu (Author), Jishun Chen (Author), Jingning Yang (Author), Xincai Hao (Author), Zhixin Liu (Author), Jixin Zhong (Author), Handong Yang (Author), Xinlong Chen (Author), Xinwen Min (Author), Jun Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To investigate the effects of Linggui Zhugan Decoction on mitochondrial and oxidative damage in rats with chronic heart failure after myocardial infarction and the related mechanisms.Methods: Chronic heart failure after myocardial infarction was established by coronary artery ligation. He...