Clinical Application of Ischemic Preconditioning in the Elderly

A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical "hormetic mechanism" by which the heart is immunized from pathological insults such as myocardial...

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Bibliographic Details
Main Authors: Pasquale Abete (Author), Francesco Cacciatore (Author), Gianluca Testa (Author), David Della-Morte (Author), Gianluigi Galizia (Author), Nicola Ferrara (Author), Franco Rengo (Author)
Format: Book
Published: SAGE Publishing, 2010-01-01T00:00:00Z.
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Summary:A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical "hormetic mechanism" by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial K ATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug in well-controlled animal and human studies in order to prevent and/or restore the age-related reduction of ischemic preconditioning.
Item Description:1559-3258
10.2203/dose-response.09-023.Abete