Nephroprotective effect of Costus pictus extract against doxorubicin-induced toxicity on Wistar rat
The present study was conducted to evaluate the nephroprotective effect of a medicinal herb Costus pictus against doxorubicin-induced toxicity. Rats were divided into six groups and treated with doxorubicin and ethanol extract of the C. pictus. Doxorubicin was administered intraperitoneally with a s...
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Published: |
Bangladesh Pharmacological Society,
2019-05-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_e3ab3d25fc034fcbbd3a652e1bfb85d8 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Muthiah Rajasekaran |e author |
| 245 | 0 | 0 | |a Nephroprotective effect of Costus pictus extract against doxorubicin-induced toxicity on Wistar rat |
| 260 | |b Bangladesh Pharmacological Society, |c 2019-05-01T00:00:00Z. | ||
| 500 | |a 10.3329/bjp.v14i2.39992 | ||
| 500 | |a 1991-0088 | ||
| 520 | |a The present study was conducted to evaluate the nephroprotective effect of a medicinal herb Costus pictus against doxorubicin-induced toxicity. Rats were divided into six groups and treated with doxorubicin and ethanol extract of the C. pictus. Doxorubicin was administered intraperitoneally with a single dose (4 mg/kg) per week for three weeks. The extract (200 or 400 mg/kg) was administered orally for 4 weeks to two doxorubicin groups. Significant changes of the serum kidney markers, albumin, urea, uric acid and creatinine, and glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, reduced glutathione and lipid peroxides in the kidney of doxorubicin-treated rat were observed. Histological features were also severely affected. However, biochemical and histological changes in the extract-treated rat were non-significant, showing that the herb is nephroprotective. The effects were comparable to the anti-oxidant vitamin E. | ||
| 546 | |a EN | ||
| 690 | |a Costus pictus | ||
| 690 | |a Doxorubicin | ||
| 690 | |a Histology | ||
| 690 | |a Nephroprotective | ||
| 690 | |a Wistar rat | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Bangladesh Journal of Pharmacology, Vol 14, Iss 2 (2019) | |
| 787 | 0 | |n https://www.banglajol.info/index.php/BJP/article/view/39992 | |
| 787 | 0 | |n https://doaj.org/toc/1991-0088 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e3ab3d25fc034fcbbd3a652e1bfb85d8 |z Connect to this object online. |