Relationships among egfr, vitamin d metabolites and pth 1-84 in ckd.

• Main Authors: K. Phelps (Author), R. Mathew (Author), K. Stote (Author), L. Hewson (Author), D. Hallenbeck (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vitamin D undergoes 25-hydroxylation in the liver (25D) and 1-alpha hydroxylation in the kidney (1,25D). Both [25D] and [1,25D] fell with GFR in surveys of patients with CKD. Because 1,25D suppresses transcription of the PTH gene, low [1,25D] is thought to be a cause of high [PTH] in CKD. To examine...