The Risk of Recrystallization: Changes to the Toxicity and Morphology of Pyrimethamine
PURPOSE. Pyrimethamine, an anti-malarial agent known to exhibit solid state polymorphism, may be purified by means of recrystallization. Recrystallization may alter the solid state chemistry of pharmaceuticals, which may impact the toxicity and/or manufacturability thereof. We evaluated the risks as...
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| Main Authors: | , , |
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| Format: | Book |
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Frontiers Media S.A.,
2014-04-01T00:00:00Z.
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