Selank effects on morphine-induced analgesia <i>in vivo</i> experiments

• Główni autorzy: A. V. Nadorova (Autor), I. V. Chernyakova (Autor), L. G. Kolik (Autor)
• Format: Książka
• Wydane: LLC "Publisher OKI", 2022-05-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.
• Notes: 2587-7836; 2686-8830; 10.37489/2587-7836-2022-1-30-35
• Keywords: morphine; selank; analgesia; drug interaction; mice; Pharmacy and materia medica; RS1-441
• Source: Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 30-35 (2022)

Background. The endogenous opioid system is involved in neuroadaptation produced by exogenous opioids. Synthesized on the basis of the regulatory peptide tuftsin, the anxiolytic selank inhibits the activity of enkephalin-degrading enzymes, increasing the level of leu-enkephalins in blood plasma. The aim of the work was to evaluate the effect of selank (0,3 and 0,9 mg/kg, i. p.) on morphine-induced analgesia in animal models. Methods. The experiments were performed in inbred male mice C57Bl/6 (n = 77). The "hot plate" test was used to evaluate the analgesic effect during thermal stimulation of nociceptors when mice were placed on a metal plate heated to 55 ± 0,5 °C, followed by registration of the latent period of the reaction 30, 60, 90, and 120 minutes after the administration of morphine. Results. Morphine at a dose of 3,0 mg/kg, i. p., caused antinociception with the maximum possible effect (MBE) of 9 %, selank at a dose of 0,9 mg/kg, without antinociception per se, when pretreated with the morphine, increased the latent reaction time, causing antinociception of 29,9 % MBE. Conclusion. For the first time the data obtained on the synergistic effect of selank and morphine in attenuation of acute somatic pain.