The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma

• Main Authors: Haoyue Xu (Author), Yongkang Zhang (Author), Linfeng Li (Author), Yanhong Ren (Author), Feng Qian (Author), Lansheng Wang (Author), Hongwei Ma (Author), Ankang Quan (Author), Hongmei Liu (Author), Rutong Yu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractTemozolomide (TMZ) is a conventional chemotherapeutic drug for glioma, however, its clinical application and efficacy is severely restricted by its drug resistance properties. O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme, which can repair the DNA damage caused by TMZ....