Super bioavailable itraconazole and its place and relevance in recalcitrant dermatophytosis: Revisiting skin levels of itraconazole and minimum inhibitory concentration data
Itraconazole, is the most commonly prescribed oral antifungal agent in India, and has a low minimum inhibitory concentration as compared to other oral antifungals, and in conjunction with the markedly high skin levels, the drug should have a predictably good clinical response which is not the consis...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Published: |
Wolters Kluwer Medknow Publications,
2021-01-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_e41b8bb482d34766a8e65b1d48f7fbf9 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kabir Sardana |e author |
| 700 | 1 | 0 | |a Sinu Rose Mathachan |e author |
| 245 | 0 | 0 | |a Super bioavailable itraconazole and its place and relevance in recalcitrant dermatophytosis: Revisiting skin levels of itraconazole and minimum inhibitory concentration data |
| 260 | |b Wolters Kluwer Medknow Publications, |c 2021-01-01T00:00:00Z. | ||
| 500 | |a 2229-5178 | ||
| 500 | |a 10.4103/idoj.IDOJ_618_20 | ||
| 520 | |a Itraconazole, is the most commonly prescribed oral antifungal agent in India, and has a low minimum inhibitory concentration as compared to other oral antifungals, and in conjunction with the markedly high skin levels, the drug should have a predictably good clinical response which is not the consistent experience of clinicians . Probably the variation in pelletization parameters might affect the bioavailability of the drug and consequently affect the serum levels. The maximum bioavailability of conventional itraconazole is 55 percent, which is neither consistent nor predictable. However, the novel itraconazole (Super bioavailable Itraconazole) with targeted drug release in the small intestine has predictable serum levels with minimum interindividual variability, which could make it a potentially useful drug in recalcitrant dermatophytosis. | ||
| 546 | |a EN | ||
| 690 | |a bioavailability | ||
| 690 | |a conventional | ||
| 690 | |a itraconazole | ||
| 690 | |a minimum inhibitory concentration | ||
| 690 | |a pharmacokinetics | ||
| 690 | |a recalcitrant dermatophytosis | ||
| 690 | |a resistance | ||
| 690 | |a super bioavailable | ||
| 690 | |a targeted drug release | ||
| 690 | |a variability | ||
| 690 | |a trichophyton | ||
| 690 | |a tinea corporis | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Indian Dermatology Online Journal, Vol 12, Iss 1, Pp 1-5 (2021) | |
| 787 | 0 | |n http://www.idoj.in/article.asp?issn=2229-5178;year=2021;volume=12;issue=1;spage=1;epage=5;aulast=Sardana | |
| 787 | 0 | |n https://doaj.org/toc/2229-5178 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e41b8bb482d34766a8e65b1d48f7fbf9 |z Connect to this object online. |