Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells
T cell activation is invariably associated with virus infections, but activation of T cells is also noted, for example, in patients with persistent bacterial infections with intracellular pathogens or localised bacterial biofilms. The latter is characterised by a destructive inflammatory process. Ma...
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| Format: | Book |
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Hindawi Limited,
2010-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_e4477f01c9fc43059fd27ef8dca8de1f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Dimitra Kotsougiani |e author |
| 700 | 1 | 0 | |a Marco Pioch |e author |
| 700 | 1 | 0 | |a Birgit Prior |e author |
| 700 | 1 | 0 | |a Volkmar Heppert |e author |
| 700 | 1 | 0 | |a G. Maria Hänsch |e author |
| 700 | 1 | 0 | |a Christof Wagner |e author |
| 245 | 0 | 0 | |a Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells |
| 260 | |b Hindawi Limited, |c 2010-01-01T00:00:00Z. | ||
| 500 | |a 2042-0099 | ||
| 500 | |a 10.4061/2010/526740 | ||
| 520 | |a T cell activation is invariably associated with virus infections, but activation of T cells is also noted, for example, in patients with persistent bacterial infections with intracellular pathogens or localised bacterial biofilms. The latter is characterised by a destructive inflammatory process. Massive infiltration of leukocytes, predominantly of polymorphonuclear neutrophils (PMNs) and of T lymphocytes, is seen. While PMN influx into sites of bacterial infection is in line with their role as "first-line defence" a role of T cells in bacterial infection has not yet been delineated. We now found evidence for activation and expansion of peripheral blood T cells and an upregulation of Toll-like receptors 1, 2, and 4 on small portions of T cells. T cells recovered from the infected site were terminally differentiated and produced interferon gamma, a cytokine known to enhance functions of phagocytic cells, leading to the conclusion that infiltrated T cells support the local immuner defence. | ||
| 546 | |a EN | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n International Journal of Inflammation, Vol 2010 (2010) | |
| 787 | 0 | |n http://dx.doi.org/10.4061/2010/526740 | |
| 787 | 0 | |n https://doaj.org/toc/2042-0099 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e4477f01c9fc43059fd27ef8dca8de1f |z Connect to this object online. |