A case of Dapsone Induced Methemoglobinemia
Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ to...
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Taylor & Francis Group,
2019-12-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_e457079e437e4eea919c1f76e23c117a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Najia Mahmood |e author |
| 700 | 1 | 0 | |a Mutti Ullah Khan |e author |
| 700 | 1 | 0 | |a Ihtisham U. L. Haq |e author |
| 700 | 1 | 0 | |a Farhat Afshan Jelani |e author |
| 700 | 1 | 0 | |a Aayesha Tariq |e author |
| 245 | 0 | 0 | |a A case of Dapsone Induced Methemoglobinemia |
| 260 | |b Taylor & Francis Group, |c 2019-12-01T00:00:00Z. | ||
| 500 | |a 2052-3211 | ||
| 500 | |a 10.1186/s40545-019-0185-y | ||
| 520 | |a Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO2 and cardio-respiratory status. If left untreated, the disease can be fatal. | ||
| 546 | |a EN | ||
| 690 | |a cyanosis | ||
| 690 | |a methemoglobinemia | ||
| 690 | |a oxidizing agent | ||
| 690 | |a tissue hypoxia | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmaceutical Policy and Practice, Vol 12, Iss 1 (2019) | |
| 787 | 0 | |n http://dx.doi.org/10.1186/s40545-019-0185-y | |
| 787 | 0 | |n https://doaj.org/toc/2052-3211 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e457079e437e4eea919c1f76e23c117a |z Connect to this object online. |