DNA instability in replicating Huntington's disease lymphoblasts

• Main Authors: Frati Luigi (Author), Ragona Giuseppe (Author), Martino Tiziana (Author), Maglione Vittorio (Author), Cannella Milena (Author), Li Guo-Min (Author), Squitieri Ferdinando (Author)
• Format: Book
• Published: BMC, 2009-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The expanded CAG repeat in the Huntington's disease (HD) gene may display tissue-specific variability (e.g. triplet mosaicism) in repeat length, the longest mutations involving mitotic (germ and glial cells) and postmitotic (neu...