Novel 2-mercapto imidazole and triazole derivatives as potent TGR5 receptor agonists
TGR5 is a bile acid G protein-coupled receptor (GPCR), which is an attractive therapeutic target for the treatment of obesity, and its highly associated Type 2 diabetes. Activation of TGR5 promotes secretion of glucagon like peptide-1 (GLP-1) and activates insulin secretion. Series of novel 2-mercap...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2019-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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