Progress in RNAi-mediated Molecular Therapy of Acute and Chronic Myeloid Leukemia

• Main Authors: Breanne Landry (Author), Juliana Valencia-Serna (Author), Hilal Gul-Uludag (Author), Xiaoyan Jiang (Author), Anna Janowska-Wieczorek (Author), Joseph Brandwein (Author), Hasan Uludag (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leukemias arise from genetic alterations in normal hematopoietic stem or progenitor cells, leading to impaired regulation of proliferation, differentiation, apoptosis, and survival of the transformed cells. With the advent of RNA interference (RNAi) and the short interfering RNA (siRNA) as its pharm...