Diphenyleneiodonium inhibits NF-κB activation and iNOS expression induced by IL-1β: involvement of reactive oxygen species
Aims: In this work, we studied the mechanisms by which diphenyleneiodonium chloride (DPI) inhibits nitric oxide (NO) synthesis induced by the pro-inflammatory cytokine interleukin-1β (IL-1) in bovine articular chondrocytes. To achieve this, we evaluated the ability of DPI to inhibit the expression a...
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| Main Authors: | , , , |
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| Format: | Book |
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Hindawi Limited,
2001-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_e4b9fc5a83c84b55b22c87958ba98126 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a A. Ferreira Mendes |e author |
| 700 | 1 | 0 | |a A. Pato Carvalho |e author |
| 700 | 1 | 0 | |a M. Margarida Caramona |e author |
| 700 | 1 | 0 | |a M. Celeste Lopes |e author |
| 245 | 0 | 0 | |a Diphenyleneiodonium inhibits NF-κB activation and iNOS expression induced by IL-1β: involvement of reactive oxygen species |
| 260 | |b Hindawi Limited, |c 2001-01-01T00:00:00Z. | ||
| 500 | |a 0962-9351 | ||
| 500 | |a 1466-1861 | ||
| 500 | |a 10.1080/09629350120080401 | ||
| 520 | |a Aims: In this work, we studied the mechanisms by which diphenyleneiodonium chloride (DPI) inhibits nitric oxide (NO) synthesis induced by the pro-inflammatory cytokine interleukin-1β (IL-1) in bovine articular chondrocytes. To achieve this, we evaluated the ability of DPI to inhibit the expression and activity of the inducible isoform of the NO synthase (iNOS) induced by IL-1. We also studied the ability of DPI to prevent IL-1-induced NF-κB activation and reactive oxygen species (ROS) production. | ||
| 546 | |a EN | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Mediators of Inflammation, Vol 10, Iss 4, Pp 209-215 (2001) | |
| 787 | 0 | |n http://dx.doi.org/10.1080/09629350120080401 | |
| 787 | 0 | |n https://doaj.org/toc/0962-9351 | |
| 787 | 0 | |n https://doaj.org/toc/1466-1861 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e4b9fc5a83c84b55b22c87958ba98126 |z Connect to this object online. |