NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?
Background/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of pr...
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Karger Publishers,
2014-02-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_e4c14bae9e6b466f9f0669b61f72d7f2 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Katarína Kuricová |e author |
| 700 | 1 | 0 | |a Veronika Tanhäuserová |e author |
| 700 | 1 | 0 | |a Lukáš Pácal |e author |
| 700 | 1 | 0 | |a Vendula Bartáková |e author |
| 700 | 1 | 0 | |a Lucie Brožová |e author |
| 700 | 1 | 0 | |a Jiří Jarkovský |e author |
| 700 | 1 | 0 | |a Kateřina Kaňková |e author |
| 245 | 0 | 0 | |a NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy? |
| 260 | |b Karger Publishers, |c 2014-02-01T00:00:00Z. | ||
| 500 | |a 1420-4096 | ||
| 500 | |a 1423-0143 | ||
| 500 | |a 10.1159/000355757 | ||
| 520 | |a Background/Aims: We have previously associated SNP 894G>T in the NOS3 gene with diabetic nephropathy (DN) using multi-locus analysis. Variant 894G>T has been widely studied as a DN susceptibility factor with contradictory results. In the present study we genotyped 894G>T in the cohort of prospectively followed type 2 diabetics with the aim to investigate its possible role in the progression of DN and development of morbidity and mortality associated with diabetes. Methods: 311 subjects with defined stage of DN were enrolled in the study and followed up for a median of 38 months. We considered three end-points: progression of DN, major cardiovascular event and all-cause mortality. Results: Considering baseline GFR, age at enrolment and diabetes duration as confounders, Cox regression analysis identified 894GT genotype as a risk factor for DN progression (HR = 1.843 [95% CI 1.088 - 3.119], P = 0.023) and 894TT genotype as a risk factor for major cardiovascular event (HR = 2.515 [95% CI 1.060 - 5.965], P = 0.036). Conclusion: We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. Based on these results NOS3 can be considered a modifier gene for DN. | ||
| 546 | |a EN | ||
| 690 | |a Polymorphism | ||
| 690 | |a Cardiovascular morbidity | ||
| 690 | |a Diabetic nephropathy | ||
| 690 | |a Nitric oxide synthase | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 690 | |a Diseases of the circulatory (Cardiovascular) system | ||
| 690 | |a RC666-701 | ||
| 690 | |a Diseases of the genitourinary system. Urology | ||
| 690 | |a RC870-923 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Kidney & Blood Pressure Research, Vol 38, Iss 1, Pp 92-98 (2014) | |
| 787 | 0 | |n http://www.karger.com/Article/FullText/355757 | |
| 787 | 0 | |n https://doaj.org/toc/1420-4096 | |
| 787 | 0 | |n https://doaj.org/toc/1423-0143 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e4c14bae9e6b466f9f0669b61f72d7f2 |z Connect to this object online. |