In silico docking and comparative ADMET profile of different glycogen synthase kinase 3 beta inhibitors as the potential leads for the development of anti-Alzheimer drug therapy

• Main Authors: Manisha Prajapat (Author), Phulen Sarma (Author), Nishant Shekhar (Author), Hardeep Kaur (Author), Sanjay Singh (Author), Subodh Kumar (Author), Harpinder Kaur (Author), Saniya Mahendiratta (Author), Amit Raj Sharma (Author), Sukhmandeep Kaur (Author), Vidya M Mahalmani (Author), Bikash Medhi (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glycogen synthase kinase 3 beta (GSK3 β) plays a key role in pathologic hyper phosphorylation of tau and plays an important role in the pathogenesis of Alzheimer's disease. In the present study, we have screened a set of potential hits in in silico platform to gain insight regarding binding pro...