Current Practices on Diagnosis, Prevention and Treatment of Post-Transplant Lymphoproliferative Disorder in Pediatric Patients after Solid Organ Transplantation: Results of ERN TransplantChild Healthcare Working Group Survey
(1) Background: Post-transplant lymphoproliferative disease (PTLD) is a significant complication of solid organ transplantation (SOT). However, there is lack of consensus in PTLD management. Our aim was to establish a present benchmark for comparison between international centers and between various...
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MDPI AG,
2021-07-01T00:00:00Z.
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| 700 | 1 | 0 | |a Luz Yadira Bravo-Gallego |e author |
| 700 | 1 | 0 | |a Emer Fitzpatrick |e author |
| 700 | 1 | 0 | |a Angel Alonso Melgar |e author |
| 700 | 1 | 0 | |a Gema Muñoz Bartolo |e author |
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| 700 | 1 | 0 | |a Esther Ramos Boluda |e author |
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| 700 | 1 | 0 | |a Julia Carlens |e author |
| 700 | 1 | 0 | |a Ulrich Baumann |e author |
| 700 | 1 | 0 | |a Charlotte Roy |e author |
| 700 | 1 | 0 | |a Christophe Chardot |e author |
| 700 | 1 | 0 | |a Elisa Benetti |e author |
| 700 | 1 | 0 | |a Mara Cananzi |e author |
| 700 | 1 | 0 | |a Elisabetta Calore |e author |
| 700 | 1 | 0 | |a Luca Dello Strologo |e author |
| 700 | 1 | 0 | |a Manila Candusso |e author |
| 700 | 1 | 0 | |a Maria Francelina Lopes |e author |
| 700 | 1 | 0 | |a Manuel João Brito |e author |
| 700 | 1 | 0 | |a Cristina Gonçalves |e author |
| 700 | 1 | 0 | |a Carmen Do Carmo |e author |
| 700 | 1 | 0 | |a Xavier Stephenne |e author |
| 700 | 1 | 0 | |a Lars Wennberg |e author |
| 700 | 1 | 0 | |a Rosário Stone |e author |
| 700 | 1 | 0 | |a Jelena Rascon |e author |
| 700 | 1 | 0 | |a Caroline Lindemans |e author |
| 700 | 1 | 0 | |a Dominik Turkiewicz |e author |
| 700 | 1 | 0 | |a Eugenia Giraldi |e author |
| 700 | 1 | 0 | |a Emanuele Nicastro |e author |
| 700 | 1 | 0 | |a Lorenzo D'Antiga |e author |
| 700 | 1 | 0 | |a Oanez Ackermann |e author |
| 700 | 1 | 0 | |a Paloma Jara Vega |e author |
| 245 | 0 | 0 | |a Current Practices on Diagnosis, Prevention and Treatment of Post-Transplant Lymphoproliferative Disorder in Pediatric Patients after Solid Organ Transplantation: Results of ERN TransplantChild Healthcare Working Group Survey |
| 260 | |b MDPI AG, |c 2021-07-01T00:00:00Z. | ||
| 500 | |a 10.3390/children8080661 | ||
| 500 | |a 2227-9067 | ||
| 520 | |a (1) Background: Post-transplant lymphoproliferative disease (PTLD) is a significant complication of solid organ transplantation (SOT). However, there is lack of consensus in PTLD management. Our aim was to establish a present benchmark for comparison between international centers and between various organ transplant systems and modalities; (2) Methods: A cross-sectional questionnaire of relevant PTLD practices in pediatric transplantation was sent to multidisciplinary teams from 17 European center members of ERN TransplantChild to evaluate the centers' approach strategies for diagnosis and treatment and how current practices impact a cross-sectional series of PTLD cases; (3) Results: A total of 34 SOT programs from 13 European centers participated. The decision to start preemptive treatment and its guidance was based on both EBV viremia monitoring plus additional laboratory methods and clinical assessment (61%). Among treatment modalities the most common initial practice at diagnosis was to reduce the immunosuppression (61%). A total of 126 PTLD cases were reported during the period 2012-2016. According to their histopathological classification, monomorphic lesions were the most frequent (46%). Graft rejection after PTLD remission was 33%. Of the total cases diagnosed with PTLD, 88% survived; (4) Conclusions: There is still no consensus on prevention and treatment of PTLD, which implies the need to generate evidence. This might successively allow the development of clinical guidelines. | ||
| 546 | |a EN | ||
| 690 | |a PTLD | ||
| 690 | |a post-transplant lymphoproliferative disorder | ||
| 690 | |a pediatric | ||
| 690 | |a solid organ transplantation | ||
| 690 | |a immunosuppression | ||
| 690 | |a Epstein-Barr virus | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Children, Vol 8, Iss 8, p 661 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/2227-9067/8/8/661 | |
| 787 | 0 | |n https://doaj.org/toc/2227-9067 | |
| 856 | 4 | 1 | |u https://doaj.org/article/e4cb0f49cb584054a82941ab9f84d7ba |z Connect to this object online. |