Global Health Priority Box: Discovering Flucofuron as a Promising Antikinetoplastid Compound
Leishmaniasis, produced by <i>Leishmania</i> spp., and Chagas disease, produced by <i>Trypanosoma cruzi</i>, affect millions of people around the world. The treatments for these pathologies are not entirely effective and produce some side effects. For these reasons, it is nec...
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| Main Authors: | , , , |
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| Format: | Book |
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MDPI AG,
2024-04-01T00:00:00Z.
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| Summary: | Leishmaniasis, produced by <i>Leishmania</i> spp., and Chagas disease, produced by <i>Trypanosoma cruzi</i>, affect millions of people around the world. The treatments for these pathologies are not entirely effective and produce some side effects. For these reasons, it is necessary to develop new therapies that are more active and less toxic for patients. Some initiatives, such as the one carried out by the Medicines for Malaria Venture, allow for the screening of a large number of compounds of different origins to find alternatives to the lack of trypanocide treatments. In this work, 240 compounds were tested from the Global Health Priority Box (80 compounds with confirmed activity against drug-resistant malaria, 80 compounds for screening against neglected and zoonotic diseases and diseases at risk of drug resistance, and 80 compounds with activity against various vector species) against <i>Trypanosoma cruzi</i> and <i>Leishmania amazonensis</i>. Flucofuron, a compound with activity against vectors and with previous activity reported against <i>Staphylococcus</i> spp. and <i>Schistosoma</i> spp., demonstrates activity against <i>L. amazonensis</i> and <i>T. cruzi</i> and produces programmed cell death in the parasites. Flucofuron seems to be a good candidate for continuing study and proving its use as a trypanocidal agent. |
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| Item Description: | 10.3390/ph17050554 1424-8247 |