Correlation between Insulin-Like Growth Factor I and Skeletal Maturity Indicators

• Main Authors: Julia Carelli DDS, MSc (Author), Camila Mattos MSc (Author), Nathaly D. Morais DDS, MSc (Author), Rafaela Scariot DDS, MSc, PhD (Author), João Armando Brancher DDS, MSc, PhD (Author), Flares Baratto-Filho DDS, MSc, PhD (Author), Erika Calvano Kuchler DDS, MSc, PhD (Author), Alexandre Moro DDS, MSc, PhD (Author)
• Format: Book
• Published: SAGE Publishing, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2333-794X; 10.1177/2333794X211011305
• Keywords: Pediatrics; RJ1-570
• Source: Global Pediatric Health, Vol 8 (2021)

Objective: The purpose of this study was to evaluate the correlation between the growth maturity indicators in orthodontic patients. Design : This cross-sectional study was performed on 37 orthodontic patients (17 males and 20 females). An anamnesis, clinical and image examination, and blood sample collection were performed. The inclusion criteria were non-syndromic Class II patients of both gender, age ranging between 10 to 16 years. The lateral cephalometric radiographs were evaluated using 6-stage cervical vertebrae maturation (CVM) technique. The hand-wrist radiographs were staged using the 11-stage skeletal maturation indicator (SMI) technique. Blood was collected in the same week of the images to quantify IGF-1 levels in serum. Data were tested for normality by Shapiro-Wilk test. The Pearson test was used to determine the correlation strength between the variables (alpha of 5%). Results : A strong correlation was observed only between SMI stages and CVM stages in the total sample (r=0.864; p<0.0001) and according to the gender (r=0.793; p<0.0001 for females; and r=0.753; p<0.0001 for males). IGF-1 was only moderately correlated with SMI stages and CVM stages. Conclusion : Hand-wrist and cervical vertebral stages were strongly correlated among them, however, IGF-1 was only moderately correlated with both skeletal maturity indicators.