Determinants of Cytochrome P450 2D6 mRNA Levels in Healthy Human Liver Tissue

• Main Authors: Miaoran Ning (Author), Julio D. Duarte (Author), Faith Stevison (Author), Nina Isoherranen (Author), Leah H. Rubin (Author), Hyunyoung Jeong (Author)
• Formato: Livro
• Publicado em: Wiley, 2019-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Cytochrome P450 2D6 (CYP2D6) is a major drug‐metabolizing enzyme that exhibits large interindividual variability. Recent studies suggest that differential transcriptional regulation of CYP2D6 in part may be responsible for the variability. In this study, we characterized potential determinants of CY...