In Vitro/In Vivo Evaluation of Clomipramine Orodispersible Tablets for the Treatment of Depression and Obsessive-Compulsive Disorder

• Main Authors: Shazia Akram Ghumman (Author), Huma Hameed (Author), Sobia Noreen (Author), Sami A. Al-Hussain (Author), Rizwana Kausar (Author), Ali Irfan (Author), Ramla Shabbir (Author), Maria Rana (Author), Amina Amanat (Author), Magdi E. A. Zaki (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The first and only antidepressant drug on the market with solid proof of clinically significant serotonin and noradrenaline reuptake inhibition is clomipramine (CLP). However, significant first-pass metabolism reduces its absorption to less than 62%. It is heavily protein-bound and broadly dispersed...