Clostridium Difficile Infection in the Nephrology Ward

Clostridium difficile is currently the most frequently identified pathogen causing antibiotic-associated diarrhea and the main cause of nosocomial diarrhea. In recent years, increases incidence of infection, severe infection, recurrent infection and mortality from Clostridium difficile infection (CD...

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Main Authors: Sylwia Dudzicz (Author), Marcin Adamczak (Author), Andrzej Więcek (Author)
Format: Book
Published: Karger Publishers, 2017-11-01T00:00:00Z.
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100 1 0 |a Sylwia Dudzicz  |e author 
700 1 0 |a Marcin Adamczak  |e author 
700 1 0 |a Andrzej Więcek  |e author 
245 0 0 |a Clostridium Difficile Infection in the Nephrology Ward 
260 |b Karger Publishers,   |c 2017-11-01T00:00:00Z. 
500 |a 1420-4096 
500 |a 1423-0143 
500 |a 10.1159/000484428 
520 |a Clostridium difficile is currently the most frequently identified pathogen causing antibiotic-associated diarrhea and the main cause of nosocomial diarrhea. In recent years, increases incidence of infection, severe infection, recurrent infection and mortality from Clostridium difficile infection (CDI) have been observed. This may be a consequence of excessive antibiotic use and spread of the hypervirulent epidemic BI/NAP1/027 strain of Clostridium difficile. The main risk factors for CDI are: antibiotic therapy, previous hospitalizations and number of comorbid conditions. Prevention of CDI mainly is focused in two directions: reducing the exposure of patients to the disease pathogen by intensifying hygiene measures, and reducing the impact of risk factors. A meta-analyses of clinical studies (observational, cohort and case control) showed significantly higher risk of CDI and CDI recurrence in patients with chronic kidney disease and increased mortality risk in chronic kidney disease patients with CDI comparing those without CDI. Increased risk of CDI in patients with chronic kidney disease can be caused by: frequent antibiotic therapy associated with numerous infections resulting in intestinal microflora dysfunction, frequent hospitalizations, older age of the patients and an impaired immune system. Among preventative measures against CDI, the use of probiotics were also studied. In patients hospitalized in nephrology ward highly significant reduction of the CDI incidence was observed after the introduction of Lactobacillus plantarum 299v as CDI prophylaxis. Therefore, the use of Lactobacillus plantarum 299v seems to be a promising method of CDI prevention in chronic kidney disease patients hospitalized in nephrology ward. 
546 |a EN 
690 |a Antibiotic therapy 
690 |a Chronic kidney disease 
690 |a Clostridium difficile 
690 |a Lactobacillus plantarum 299v 
690 |a Dermatology 
690 |a RL1-803 
690 |a Diseases of the circulatory (Cardiovascular) system 
690 |a RC666-701 
690 |a Diseases of the genitourinary system. Urology 
690 |a RC870-923 
655 7 |a article  |2 local 
786 0 |n Kidney & Blood Pressure Research, Vol 42, Iss 5, Pp 844-852 (2017) 
787 0 |n https://www.karger.com/Article/FullText/484428 
787 0 |n https://doaj.org/toc/1420-4096 
787 0 |n https://doaj.org/toc/1423-0143 
856 4 1 |u https://doaj.org/article/e552e81c814b408cbdae46d26cc7ce9c  |z Connect to this object online.