Renal Fibrosis in Murine Obstructive Nephropathy Is Attenuated by Depletion of Monocyte Lineage, Not Dendritic Cells

• Main Authors: Yuichi Machida (Author), Koichiro Kitamoto (Author), Yasukatsu Izumi (Author), Masayuki Shiota (Author), Junji Uchida (Author), Yukimi Kira (Author), Tatsuya Nakatani (Author), Katsuyuki Miura (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: The role of renal dendritic cells (DCs) in renal fibrosis is unknown. The present study was conducted to examine the relative role of renal DCs and macrophages in the development of renal fibrosis in murine obstructive nephropathy. CD11c-diphtheria toxin receptor (DTR) transgenic mice and...