Pharmacokinetics, tissue distribution, and antitumor activity of a novel compound, NY-2, in non-small cell lung cancer
Introduction: ZLDI-8, which has a relatively strong antitumor activity, is an inhibitor of ADAM-17 and acts on the Notch signaling pathway. To further optimize its structure and improve its activity, a series of derivatives of ZLDI-8 was synthesized. NY-2 was the most effective derivative based on p...
Saved in:
Main Authors: | Yingshi Zhang (Author), Chang Xu (Author), Xiangbo Xu (Author), Lingxiang Ma (Author), Ruolan Li (Author), Zihua Xu (Author), Qingchun Zhao (Author) |
---|---|
Format: | Book |
Published: |
Frontiers Media S.A.,
2023-01-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The ADAM17 inhibitor ZLDI-8 sensitized hepatocellular carcinoma cells to sorafenib through Notch1-integrin β-talk
by: Chang Xu, et al.
Published: (2024) -
Upregulation of nuclear division cycle 80 contributes to therapeutic resistance via the promotion of autophagy-related protein-7-dependent autophagy in lung cancer
by: Xi Chen, et al.
Published: (2022) -
A Novel Small-Molecule Inhibitor of SREBP-1 Based on Natural Product Monomers Upregulates the Sensitivity of Lung Squamous Cell Carcinoma Cells to Antitumor Drugs
by: De-Bin Ma, et al.
Published: (2022) -
Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition
by: Shaohua Xu, et al.
Published: (2022) -
Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway
by: Xu HL, et al.
Published: (2015)