Green synthesis and biological evaluation of novel 5-fluorouracil derivatives as potent anticancer agents

• Main Authors: Farhat Jubeen (Author), Aisha Liaqat (Author), Misbah Sultan (Author), Sania Zafar Iqbal (Author), Imran Sajid (Author), Farooq Sher (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study reports the formation of 5-FU co-crystals with four different pharmacologically safe co-formers; Urea, Thiourea, Acetanilide and Aspirin using methanol as a solvent. Two fabrication schemes were followed i.e., solid-state grinding protocol, in which API and co-formers were mixed through v...