Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
Background: The arylamine N-acetyltransferase 2 (NAT2) is a key enzyme in the biotransformation of xenobiotics. NAT2 gene polymorphisms have been associated with the risk of isoniazid hepatotoxicity and these polymorphisms change among different populations. Aim: The objective of this study is to in...
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| Main Authors: | , |
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| Format: | Book |
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Taylor & Francis Group,
2017-08-01T00:00:00Z.
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| Summary: | Background: The arylamine N-acetyltransferase 2 (NAT2) is a key enzyme in the biotransformation of xenobiotics. NAT2 gene polymorphisms have been associated with the risk of isoniazid hepatotoxicity and these polymorphisms change among different populations. Aim: The objective of this study is to investigate NAT2 polymorphisms in order to predict the prevalence of NAT2 phenotype in an Algerian population. Subjects and methods: Genotyping of NAT2 was done using a PCR-RFLP method. Haplotype was analysed using the software package PHASE, version 2.0. Results: The major haplotypes were NAT2*5B (23.72%), NAT2*6 A (18.61%), NAT2*4 (14.60%) and NAT2*5 F (10%). The average of the expected slow acetylator phenotype was 53%. Conclusion: Our results suggest that the high frequency of slow acetylator phenotype requires investigation into its possible association with ATDH. |
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| Item Description: | 0301-4460 1464-5033 10.1080/03014460.2017.1311373 |