Direct Delivery of MicroRNA96 to the Lungs Reduces Progression of Sugen/Hypoxia-Induced Pulmonary Hypertension in the Rat

• Auteurs principaux: Craig K. Docherty (Auteur), Nina Denver (Auteur), Simon Fisher (Auteur), Margaret Nilsen (Auteur), Dianne Hillyard (Auteur), Rebecca L. Openshaw (Auteur), Hicham Labazi (Auteur), Margaret R. MacLean (Auteur)
• Format: Livre
• Publié: Elsevier, 2020-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hypertension in rats. Female rats were dosed with sugen (3...