Direct Delivery of MicroRNA96 to the Lungs Reduces Progression of Sugen/Hypoxia-Induced Pulmonary Hypertension in the Rat

• Main Authors: Craig K. Docherty (Author), Nina Denver (Author), Simon Fisher (Author), Margaret Nilsen (Author), Dianne Hillyard (Author), Rebecca L. Openshaw (Author), Hicham Labazi (Author), Margaret R. MacLean (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hypertension in rats. Female rats were dosed with sugen (3...