Direct Delivery of MicroRNA96 to the Lungs Reduces Progression of Sugen/Hypoxia-Induced Pulmonary Hypertension in the Rat
The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hypertension in rats. Female rats were dosed with sugen (3...
Saved in:
Main Authors: | Craig K. Docherty (Author), Nina Denver (Author), Simon Fisher (Author), Margaret Nilsen (Author), Dianne Hillyard (Author), Rebecca L. Openshaw (Author), Hicham Labazi (Author), Margaret R. MacLean (Author) |
---|---|
Format: | Book |
Published: |
Elsevier,
2020-12-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
MicroRNA-212-5p, an anti-proliferative miRNA, attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents
by: Tianji Chen, et al.
Published: (2022) -
Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast Cancer
by: Sherihan AbdelHamid, et al.
Published: (2021) -
Using extracellular matrix derived from sugen-chronic hypoxia lung tissue to study pulmonary arterial hypertension
by: Patrick A. Link, et al.
Published: (2023) -
MicroRNA-96 Promotes Vascular Repair in Oxygen-Induced Retinopathy-A Novel Uncovered Vasoprotective Function
by: Michel Desjarlais, et al.
Published: (2020) -
The biased apelin receptor agonist, MM07, reverses Sugen/hypoxia-induced pulmonary arterial hypertension as effectively as the endothelin antagonist macitentan
by: Thomas L. Williams, et al.
Published: (2024)