Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression

• Main Authors: Chaofang Lei (Author), Zhigang Chen (Author), Lili Fan (Author), Zhe Xue (Author), Jianbei Chen (Author), Xihong Wang (Author), Zhen Huang (Author), Yinian Men (Author), Mingzhi Yu (Author), Yueyun Liu (Author), Jiaxu Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Paeoniflorin (PF) represents the major bioactive constituent of the traditional Chinese medicine plant Paeonia suffruticosa (Ranunculaceae), which has a long history as a folk medicine in Asian. Paeoniflorin, a bitter pinene monoterpene glycoside, has antidepressant effects, but its pote...