Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis

Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for t...

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Main Authors: Evangelos Polymeropoulos (Author), Pantelis Bagos (Author), Maria Papadimitriou (Author), Ioannis Rizos (Author), Efstratios Patsouris (Author), Ioannis Toumpoulis (Author)
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Published: Tabriz University of Medical Sciences, 2016-06-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Evangelos Polymeropoulos  |e author 
700 1 0 |a Pantelis Bagos  |e author 
700 1 0 |a Maria Papadimitriou  |e author 
700 1 0 |a Ioannis Rizos  |e author 
700 1 0 |a Efstratios Patsouris  |e author 
700 1 0 |a Ioannis Toumpoulis  |e author 
245 0 0 |a Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis 
260 |b Tabriz University of Medical Sciences,   |c 2016-06-01T00:00:00Z. 
500 |a 2228-5881 
500 |a 2251-7308 
500 |a 10.15171/apb.2016.033 
520 |a Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for the prevention of postoperative AF in cardiac surgery. Methods: A systematic search of PubMed, EMBASE, Google Scholar, the Cochrane Library, and clinical trial registries, was performed. 9 studies, published from August 2001 to May 2015, were included, with a total of 1,037 patients. Patients were randomized to receive vitC, or placebo. Results: Cardiac surgery patients who received vitC as prophylaxis, had a significantly lower incidence of postoperative AF (random effects OR=0.478, 95% CI 0.340 - 0.673, P < 10-4). No significant heterogeneity was detected across the analyzed studies (I2=21.7%), and no publication bias or other small study-related bias was found. Conclusion: Our findings suggest that VitC is effective as prophylaxis for the prevention of postoperative AF. The administration of vitC may be considered in all patients undergoing cardiac surgery. 
546 |a EN 
690 |a Post-operative atrial fibrillation 
690 |a Vitamin C 
690 |a CABG 
690 |a Valvular surgery 
690 |a Cardiac surgery 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Advanced Pharmaceutical Bulletin, Vol 6, Iss 2, Pp 243-250 (2016) 
787 0 |n http://journals.tbzmed.ac.ir/APB/Manuscript/APB-6-243.pdf 
787 0 |n https://doaj.org/toc/2228-5881 
787 0 |n https://doaj.org/toc/2251-7308 
856 4 1 |u https://doaj.org/article/e62c75b176bc4af9a11f1235f8db7314  |z Connect to this object online.