Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis
Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for t...
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Tabriz University of Medical Sciences,
2016-06-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_e62c75b176bc4af9a11f1235f8db7314 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Evangelos Polymeropoulos |e author |
700 | 1 | 0 | |a Pantelis Bagos |e author |
700 | 1 | 0 | |a Maria Papadimitriou |e author |
700 | 1 | 0 | |a Ioannis Rizos |e author |
700 | 1 | 0 | |a Efstratios Patsouris |e author |
700 | 1 | 0 | |a Ioannis Toumpoulis |e author |
245 | 0 | 0 | |a Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis |
260 | |b Tabriz University of Medical Sciences, |c 2016-06-01T00:00:00Z. | ||
500 | |a 2228-5881 | ||
500 | |a 2251-7308 | ||
500 | |a 10.15171/apb.2016.033 | ||
520 | |a Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for the prevention of postoperative AF in cardiac surgery. Methods: A systematic search of PubMed, EMBASE, Google Scholar, the Cochrane Library, and clinical trial registries, was performed. 9 studies, published from August 2001 to May 2015, were included, with a total of 1,037 patients. Patients were randomized to receive vitC, or placebo. Results: Cardiac surgery patients who received vitC as prophylaxis, had a significantly lower incidence of postoperative AF (random effects OR=0.478, 95% CI 0.340 - 0.673, P < 10-4). No significant heterogeneity was detected across the analyzed studies (I2=21.7%), and no publication bias or other small study-related bias was found. Conclusion: Our findings suggest that VitC is effective as prophylaxis for the prevention of postoperative AF. The administration of vitC may be considered in all patients undergoing cardiac surgery. | ||
546 | |a EN | ||
690 | |a Post-operative atrial fibrillation | ||
690 | |a Vitamin C | ||
690 | |a CABG | ||
690 | |a Valvular surgery | ||
690 | |a Cardiac surgery | ||
690 | |a Therapeutics. Pharmacology | ||
690 | |a RM1-950 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Advanced Pharmaceutical Bulletin, Vol 6, Iss 2, Pp 243-250 (2016) | |
787 | 0 | |n http://journals.tbzmed.ac.ir/APB/Manuscript/APB-6-243.pdf | |
787 | 0 | |n https://doaj.org/toc/2228-5881 | |
787 | 0 | |n https://doaj.org/toc/2251-7308 | |
856 | 4 | 1 | |u https://doaj.org/article/e62c75b176bc4af9a11f1235f8db7314 |z Connect to this object online. |